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PERIODICAL
FASTING AND CALORIC RESTRICTION FOR LIFE EXTENSION,
DISEASE TREATMENT AND CREATIVITY.
(clinical and experimental data)
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FASTING AND CALORIC RESTRICTION PREVENT AND CURE DISEASES
(Evidence) |
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2005
Department of Internal Medicine,
Division of Endocrinology and Diabetes, University
Hospital, Zurich, Switzerland.
OBJECTIVE: To determine whether
systematic evaluation of cognitive function by the
Mini-Mental State Examination (MMSE) allows the objective
detection and documentation of cognitive deterioration
in patients referred for evaluation of suspected hypoglycaemic
disorders by the 72-h fast. DESIGN: Prospective case
series. METHODS: In 50 patients referred for evaluation
of suspected hypoglycaemic disorders, the MMSE score
(maximum 30 points) was assessed at the start and
at the end of the fast. RESULTS: The fast was terminated
before 72 h in 14 patients because they developed
neuroglycopenic symptoms due to hypoglycaemic disorders.
Their MMSE score fell from a median of 29 points (range
20-30) at the beginning to 17 points (range 0-24)
at the termination of the fast. The score dropped
by > or =6 points in all patients with hypoglycaemic
disorders. Median (range) plasma glucose concentration
at the end of the fast was 2.1 (1.1-2.5) mmol/l. Thirty-six
individuals developed no neuroglycopenic symptoms
throughout the 72-h fast, their MMSE score remained
between 27 and 30 throughout the fast and their median
plasma glucose concentration dropped to 2.9 (2-3.6)
mmol/l. CONCLUSIONS: Systematic evaluation of cognitive
function by the MMSE at the beginning and at the termination
of the fast allows objective determination and documentation
of the deterioration of the cognitive state in patients
with hypoglycaemic disorders. A decline in the cognitive
performance by > or =6 points in the MMSE score
rather than a distinct plasma glucose concentration
should be used as the criterion to terminate the prolonged
fast before 72 h.
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2000
Faculty of Food Science and Biotechnology,
Pukyong National University; 599-1 Daeyeon-Dong, Nam-Gu,
Pusan 608-737, Korea.
This study was to evaluate the
effect of dietary restriction (DR) on lifespan and
oxidative stress of dementia mouse model SAMP8 with
impaired learning and memory. SAMP8 female mice were
fed either ad libitum (AL) or fed 60% of food intake
of AL. Results showed that basal metabolic rates (BMR)
were significantly lower (15 to 22%) in DR with increased
median and maximum lifespans, suggesting feed and
gross efficiencies were significantly lower in DR
than in AL. Grading score of senescence resulted in
a marked improvement about 2-fold by DR compared with
AL. The amounts of lipofuscin at 12 months were significantly
lowered 16% in DR than that of AL. Median and maximal
lifespans significantly increased (28.5% and 16.4%,
respectively) by DR, and also lowered superoxide radical
about 15~45% in DR compared with AL at 4, 8 and 12
months of age. On the other hand, superoxide dismutase
(SOD) activities were higher (about 15~30%) in DR
than those in AL group of SAMP8 except for 4 months
of age. Our results suggest that 40% calorie restricted
SAMP8 can effectively suppress dementia-related abnormalities
during aging.
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1991
ABSTRACT: During the fasting
dietetic therapy (FDT), 89 patients aged 46 to 75
years with mental disorders of nonpsychotic character
(neurosis-like, neurotic and affective) were examined.
The time-course of changes in the clinical status
of patients with cerebral atherosclerosis, essential
hypertension, slow-progredient schizophrenia, cyclothymia
and manic-depressive psychosis, neuroses and lingering
neurotic reactions during the FDT is described. The
beneficial results in the form of considerable improvement
and improvement of the mental status were attained
in 83.2% of the patients. The elderly patients were
found to tolerate FDT well. Side effects and somatic
complications were recorded in 6 patients and were
not serious. Based on the data obtained the FDT can
be recommended for use on a wider basis in the management
of elderly patients with borderline mental disorders.
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