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PERIODICAL
FASTING AND CALORIC RESTRICTION FOR LIFE EXTENSION,
DISEASE TREATMENT AND CREATIVITY.
(clinical and experimental data)
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FASTING AND CALORIC RESTRICTION PREVENT AND CURE DISEASES
(Evidence) |
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2004
Department of Public Health,
Hamamatsu University School of Medicine, Japan.
Low-energy diets and fasting
have suppressive effects on rheumatoid arthritis.
It was reported recently that urine levels of pentosidine
(i.e., an advanced glycation end product formed by
glycosylation) is associated with the activity of
rheumatoid arthritis. We conducted a regimen of caloric
restriction combined with fasting in patients with
rheumatoid arthritis, and then evaluated urinary pentosidine
levels. Ten patients with rheumatoid arthritis underwent
a 54-day caloric restriction program. Urinary pentosidine
levels were measured and the Lansbury Index were determined
by examining the clinical features, blood biochemistry
and the inflammation activity of rheumatoid arthritis
on days 0, 25 and 54. On day 0, the mean urinary pentosidine
level of patients with rheumatoid arthritis was significantly
higher than that of the control subjects. On day 54,
the mean body weight had reduced due to caloric restriction.
The mean values of the erythrocyte sedimentation rate
and the Lansbury Index of patients both significantly
decreased during the study. In addition, although
the urinary pentosidine levels showed no significant
difference between day 0 and 25, it was significantly
decreased at the end of the study (day 54). The study
showed that under a low energy diet a reduction of
disease activity in rheumatoid arthritis was accompanied
with a reduction of the urinary pentosidine.
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2001
Department of Public Health,
Hamamatsu University School of Medicine, Shizuoka,
Japan.
Fasting alters various hormonal
and immune conditions. It has been reported that delayed
type immune response to the injection of keyhole limpet
hemocyanin was depressed by short-term fasting. In
this study, we adopted the computer-assisted image
analyzer for histopathological analysis and evaluated
the influence of short-term fasting on allergic contact
dermatitis induced by 2,4-dinitrofluorobenzene (DNFB).
Mice were sensitized by painting of DNFB to the abdomen.
After the sensitization, mice were challenged by DNFB
painting to the ear. Fasting started 24 hour before
(48-hour fasted group) or immediately after (24-hour
fasted group) the challenging. Fasting without DNFB
treatment did not induce remarkable change of ear
thickness, ear tissue, serum albumin, serum total
protein, serum glutamic oxaloacetic transaminase,
serum glutamic pyruvic transaminase. or serum creatine
phosphokinase. In contrast, lasting suppressed the
increment of ear thickness in the DNFB-treated group
in this study. We could also demonstrate, using the
computerized image analyzer, that both lymphocyte
infiltration and the edema in the dermis were suppressed
in fasted mice treated with DNFB. Further, edema in
the dermis was inhibited more strongly in 48-hour
fasted mice than in 24-hour lasted mice. These findings
indicate that short-term fasting induce histopathological
changes in the state of contact dermatitis.
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1998
Laboratory of Nutritional
and Molecular Regulation, National Cancer Institute,
Frederick Cancer Research and Development Center,
Maryland 21702-1201, USA
In rodents calorie restriction
(CR) reduces cancer incidence, improves health by
delaying age-related declines in physiologic measures,
and extends both median and maximal life span. The
mechanisms underlying the various beneficial effects
of CR remain undefined. In this study, heterozygous
p53-deficient (p53(+/-)) mice (in which the inactivation
of one allele of the p53 tumor suppressor gene increases
susceptibility to spontaneous and carcinogen-induced
tumor development) and wild-type (WT) litter mates
were subjected to a two-stage skin carcinogenesis
protocol with 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol-13-acetate.
Instead of skin carcinomas, however, the chemical
treatment protocol caused ulcerous skin lesions, and
89% of mice fed ad libitum died from infection/septicemia.
When WT mice were restricted to 60% of the average
calorie intake of the respective ad libitum group,
however, only 33% developed such lesions, and the
CR mice survived twice as long on average as the ad
libitum mice. CR also extended life span in p53(+/-)
mice, but 50% of p53(+/-) mice subjected to CR still
developed skin ulcers and mean life span was shorter
than that seen in WT mice. Differences in response
to CR between WT and p53(+/-) mice may be due to the
reduction in p53 gene dosage, dissimilarity in the
application of the CR treatment, or both. These results
suggest that some of the beneficial effects of CR
may need full expression of p53 for complete realization.
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1983
Twenty patients with arthritis
and various skin diseases were studied on a metabolic
ward during a 2-week period of modified fast followed
by a 3-week period of vegetarian diet. During fasting,
arthralgia was less intense in many subjects. In some
types of skin diseases (pustulosis palmaris et plantaris
and atopic eczema) an improvement could be demonstrated
during the fast. During the vegan diet, both signs
and symptoms returned in most patients, with the exception
of some patients with psoriasis who experienced an
improvement. The concentrations of lactoferrin in
serum reflect the turnover and activity of neutrophil
leukocytes. When this protein was initially increased
it fell to normal values in most cases. The improvement
or impairment of signs and symptoms was related to
the lactoferrin levels in serum.
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Urticaria also called nettle-rash or hives or wheals
in a common language, simply means itching with rash.
Medically, urticaria may be defined as skin eruption,
which is allergic in origin and is characterized by
profound itching, red circular or irregularly shaped
eruption on any part of the body. These eruptions can
remain for variable period, anywhere between few seconds
to even hours, on the body. They have tendency to disappear
and reappear. They tend to disappear without leaving
behind any trace.
| Urticaria is an allergic
skin disorder. Characteristically the skin eruptions
are erythematous, raised above the skin level,
with intense itching and usually worse by itching,
with slight local warmth. |
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1992
Department of Dermatology,
Oita Medical University, Japan.
We used fasting diet
therapy with a 28-year-old woman with chronic
urticaria who responded only to systemic administration
of glucocorticosteroids. The rashes began
to decrease on the third therapeutic day and
completely disappeared on the 11th day. Although
the eruptions relapsed three days after the
termination of the therapy, they were milder
than previous ones. We also discussed the
possible efficacy of fasting diet therapy
for chronic urticaria as reported in the literature.
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