HOT ANTI-AGING NEWS 
Search 
Tamiflu sale!
FASTING / LOW CALORIE PROGRAMS
on the Adriatic Coast
The Anti-Aging Fasting Program consists of a 7-28 days program (including 3 - 14 fasting days). 7-28-day low-calorie diet program is also available .
More information
   
 "ANTI-AGING": is it true? 
 
Surprising but true: by several techniques -- some of them amazingly simple -- you can probably extend your lifespan very significantly, and live to what most people would now consider to be a fantastic age -- 140 years or perhaps more, if you start in early adulthood.

The "fountain of eternal youth" has been a recurring theme in literature since ancient times. Now, science is making significant progress in understanding the riddle of what happens when we age -- and evaluating techniques which can slow or even reverse the process.

Some techniques -- such as a vegetarian diet, fasting, and more recently caloric restriction (low-calorie dieting) -- are well-established for their reputed benefits, and have dedicated groups of followers. Today, evidence is accumulating which not only confirms many of the beliefs, but provides data suggesting that there are additional benefits too.

On this website you can find a detailed overview not only of the above-mentioned techniques, but of the whole subject of aging, both from a practical and theoretical point of view -- and how to prevent it. We give information about mechanisms and techniques; and also pointers to likely future developments which may extend potential lifespan even further.

Fasting - your route to prosperity?

We are not experts in "how to prosper" and it is not our business to give you financial advice. But we do suggest that you probably have great potential which at present is unused. Fasting may not give you instant prosperity; but from experience it is predictable that it will clear your brain and give you "more smarts". And a cool head and sharper brain, combined with general good health, may well help you to achieve success which formerly eluded you...
 
 
                  
 CONFERENCES 

Adriatic Anti-Aging Seminar
May 18-20, 2005,
Brela (Makarska rivera), Croatia

 
         
 INFO 

Dr. Roy Walford says about Caloric Restriction
as seen on Never Say Die: Eat Less - Live Longer
 
         
 DATABASE 
 
 
 
   
   
Physiol Res. 2005;54(1):33-9.
Short-term very low calorie diet reduces oxidative stress in obese type 2 diabetic patients.
Skrha J, Kunesova M, Hilgertova J, Weiserova H, Krizova J, Kotrlikova E.
Third Department of Internal Medicine, First Faculty of Medicine, Charles University, U nemocnice 1, 128 08 Prague 2, Czech Republic.

Oxidative stress is higher in obese diabetic than in non-diabetic subjects. This pilot study evaluates oxidative stress during short-term administration of a very low calorie diet in obese persons.
   
   
Endocrinology. 2005 May 26.
The Role of Oxidative Stress in relation to Caloric Restriction and Longevity.
Gredilla R, Barja G.
Department of Animal Physiology-II, Faculty of Biology, Complutense University, Madrid 28040, Spain.

Reduction of the caloric intake without malnutrition is one of the most consistent experimental interventions increasing mean and maximum life span in different species. For over seventy years caloric restriction has been studied, and during the last years the number of investigations on such nutritional intervention and aging has dramatically increased.
   
   
   
Clin Gastroenterol Hepatol. 2005 Mar;3(3):271-8.
Relationship of aging and tobacco use with the development of aberrant crypt foci in a predominantly African-American population.
Moxon D, Raza M, Kenney R, Ewing R, Arozullah A, Mason JB, Carroll RE.
Department of Medicine, University of Illinois at Chicago and Chicago Veterans Administration Medical Center, Chicago, Illinois 60612, USA.

In clinical studies, diminished folate availability appears to increase the risk for colorectal neoplasms. Additionally, alcohol and tobacco use are associated with an increased risk for colon cancer, but the early pathologic events by which these agents promote neoplastic transformation are not well understood.
   
   
   
Mech Ageing Dev. 2005 May 28.
Rapid and reversible induction of the longevity, anticancer and genomic effects of caloric restriction.
Spindler SR.
Department of Biochemistry, University of California, Riverside, CA 92521, USA.

It is widely held that caloric restriction (CR) extends lifespan by preventing or reducing the age-related accumulation of irreversible molecular damage. In contrast, our results suggest that CR can act rapidly to begin life and health span extension, and that its rapid genomic effects are closely linked to its health effects.
   
   
   
J Bioenerg Biomembr. 2005 Apr;37(2):83-90.
Dietary restriction at old age lowers mitochondrial oxygen radical production and leak at complex I and oxidative DNA damage in rat brain.
Sanz A, Caro P, Ibanez J, Gomez J, Gredilla R, Barja G.
Department of Animal Physiology-II, Faculty of Biological Sciences, Complutense University, Madrid, 28040, Spain.

Previous studies in mammalian models indicate that the rate of mitochondrial reactive oxygen species ROS production and the ensuing modification of mitochondrial DNA (mtDNA) link oxidative stress to aging rate.
   
   
   
Physiol Res. 2005;54(1):33-9.
Short-term very low calorie diet reduces oxidative stress in obese type 2 diabetic patients.
Skrha J, Kunesova M, Hilgertova J, Weiserova H, Krizova J, Kotrlikova E.
Third Department of Internal Medicine, First Faculty of Medicine, Charles University, U nemocnice 1, 128 08 Prague 2, Czech Republic.

Oxidative stress is higher in obese diabetic than in non-diabetic subjects. This pilot study evaluates oxidative stress during short-term administration of a very low calorie diet in obese persons.
   
   
   
J La State Med Soc. 2005 Jan;157 Spec No 1:S50-5.
Behavior and lifestyle: approaches to treatment of obesity.
Williamson DA, Stewart TM.
Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA

The increasing prevalence of overweight and obesity in adults and children demonstrates a steadily growing epidemic. This rising rate of obesity is associated with obesity related comorbidities including cardiovascular disease, hypertension, some cancers, joint disease, and particularly, type 2 diabetes.
   
   
   
Nat Rev Mol Cell Biol. 2005 Apr;6(4):298-305.
Calorie restriction, SIRT1 and metabolism: understanding longevity.
Bordone L, Guarente L.
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

Calorie restriction (CR) is the only experimental manipulation that is known to extend the lifespan of a number of organisms including yeast, worms, flies, rodents and perhaps non-human primates. In addition, CR has been shown to reduce the incidence of age-related disorders (for example, diabetes, cancer and cardiovascular disorders) in mammals.
   
   
   
Ageing Res Rev. 2005 Jan;4(1):55-65.
Lessons learned from gene expression profile studies of aging and caloric restriction.
Park SK, Prolla TA.
Department of Genetics and Medical Genetics, University of Wisconsin, 5302B Genetics building, 445 Henry Mall, Madison, WI 53706, USA.

To examine molecular events associated with aging and its retardation by caloric restriction (CR), we have employed high-density oligonucleotide microarrays to define transcriptional patterns in mouse tissues, including skeletal muscle, brain, heart, and adipose.
 

   
    The anti-aging story (summary)
Introduction. Statistical review. Your personal aging curve
  Aging and Anti-aging. Why do we age?
    2.1  Aging forces (forces that cause aging) 
     
Internal (free radicals, glycosylation, chelation etc.) 
External (Unhealthy diet, lifestyle, wrong habits, environmental pollution, stress, poverty-change "poverty zones", or take it easy. etc.) 
    2.2 Anti-aging forces
     
Internal (apoptosis, boosting your immune system, DNA repair, longevity genes) 
External (wellness, changing your environment; achieving comfortable social atmosphere in your life, regular intake of anti-aging drugs, use of replacement organs, high-tech medicine, exercise)
    2.3 Aging versus anti-aging: how to tip the balance in your favour!
 
    3.1 Caloric restriction and fasting extend lifespan and decrease all-cause mortality (Evidence)
      Human studies
Monkey studies
Mouse and rat studies
Other animal studies
    3.2 Fasting and caloric restriction prevent and cure diseases (Evidence)
        Obesity
Diabetes
Hypertension and Stroke
Skin disorders
Mental disorders
Neurogical disorders
Asthmatic bronchitis, Bronchial asthma
Bones (osteoporosis) and fasting
Arteriosclerosis and Heart Disease
Cancer and caloric restriction
Cancer and fasting - a matter of controversy
Eye diseases
Chronic fatigue syndrome
Sleeping disorders
Allergies
Rheumatoid arthritis
Gastrointestinal diseases
Infertility
Presbyacusis
    3.3 Fasting and caloric restriction produce various
      biological effects. Effects on:
        Energy metabolism
Lipids metabolism
Protein metabolism and protein quality
Neuroendocrine and hormonal system
Immune system
Physiological functions
Reproductive function
Radio-sensitivity
Apoptosis
Cognitive and behavioral functions
Biomarkers of aging
    3.4 Mechanisms: how does calorie restriction retard aging and boost health?
        Diminishing of aging forces
  Lowering of the rate of gene damage
  Reduction of free-radical production
  Reduction of metabolic rate (i.e. rate of aging)
  Lowering of body temperature
  Lowering of protein glycation
Increase of anti-aging forces
  Enhancement of gene reparation
  Enhancement of free radical neutralisation
  Enhancement of protein turnover (protein regeneration)
  Enhancement of immune response
  Activation of mono-oxygenase systems
  Enhance elimination of damaged cells
  Optimisation of neuroendocrine functions
    3.5 Practical implementation: your anti-aging dieting
        Fasting period.
Re-feeding period.
Safety of fasting and low-calorie dieting. Precautions.
      3.6 What can help you make the transition to the low-calorie life style?
        Social, psychological and religious support - crucial factors for a successful transition.
Drugs to ease the transition to caloric restriction and to overcome food cravings (use of adaptogenic herbs)
Food composition
Finding the right physician
    3.7Fasting centers and fasting programs.
  Food to eat. Dishes and menus.
    What to eat on non-fasting days. Dishes and menus. Healthy nutrition. Relation between foodstuffs and diseases. Functional foods. Glycemic index. Diet plan: practical summary. "Dr. Atkins", "Hollywood" and other fad diets versus medical science
     

Vegetables
Fruits
Bread, cereals, pasta, fiber
Glycemic index
Fish
Meat and poultry
Sugar and sweet
Legumes
Fats and oils
Dairy and eggs
Mushrooms
Nuts and seeds
Alcohol
Coffee
Water
Food composition

  Anti-aging drugs and supplements
    5.1 Drugs that are highly recommended
      (for inclusion in your supplementation anti-aging program)
        Vitamin E
Vitamin C
Co-enzyme Q10
Lipoic acid
Folic acid
Selenium
Flavonoids, carotenes
DHEA
Vitamin B
Carnitin
SAM
Vinpocetine (Cavinton)
Deprenyl (Eldepryl)
    5.2 Drugs with controversial or unproven anti-aging effect, or awaiting other evaluation (side-effects)
        Phyto-medicines, Herbs
HGH
Gerovital
Melatonin
      5.3 Drugs for treatment and prevention of specific diseases of aging. High-tech modern pharmacology.
        Alzheimer's disease and Dementia
Arthritis
Cancer
Depression
Diabetes
Hyperlipidemia
Hypertension
Immune decline
Infections, bacterial
Infections, fungal
Memory loss
Menopause
Muscle weakness
Osteoporosis
Parkinson's disease
Prostate hyperplasia
Sexual disorders
Stroke risk
Weight gaining
    5.4 The place of anti-aging drugs in the whole
      program - a realistic evaluation
 
    6.1 Early diagnosis of disease - key factor to successful treatment.
      Alzheimer's disease and Dementia
Arthritis
Cancer
Depression
Diabetes
Cataracts and Glaucoma
Genetic disorders
Heart attacks
Hyperlipidemia
Hypertension
Immune decline
Infectious diseases
Memory loss
Muscle weakness
Osteoporosis
Parkinson's disease
Prostate hyperplasia
Stroke risk
Weight gaining
    6.2 Biomarkers of aging and specific diseases
    6.3 Stem cell therapy and therapeutic cloning
    6.4 Gene manipulation
    6.5 Prosthetic body-parts, artificial organs
        Blood
Bones, limbs, joints etc.
Brain
Heart & heart devices
Kidney
Liver
Lung
Pancreas
Spleen
    6.6 Obesity reduction by ultrasonic treatment
  Physical activity and aging. Experimental and clinical data.
        Aerobic exercises
Stretching
Weight-lifting - body-building
Professional sport: negative aspects
 
  Conclusion: the whole anti-aging program
    9.1 Modifying your personal aging curve
      Average life span increment. Expert evaluation.
     
Periodic fasting and caloric restriction can add 40 - 50 years to your lifespan
Regular intake of anti-aging drugs can add 20-30 years to your lifespan
Good nutrition (well balanced, healthy food, individually tailord diet) can add 15-25 years to your lifespan
High-tech bio-medicine service can add 15-25 years to your lifespan
Quality of life (prosperity, relaxation, regular vocations) can add 15-25 years to your lifespan
Regular exercise and moderate physical activity can add 10-20 years to your lifespan
These approaches taken together can add 60-80 years to your lifespan, if you start young (say at age 20). But even if you only start later (say at 45-50), you can still gain 30-40 years


Click image
to view
    9.2 The whole anti-aging life style - brief summary
Products
    References
        The whole anti-aging program: overview